Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.
A Simple Approach to Sensor Discovery and Fabrication on Self-Assembled Monolayers on Glass(full pdf)
Lourdes Basabe-Desmonts, Joris Beld, Rebecca S. Zimmerman, Jordi Hernando, Petra Mela, María F. García Parajó, Niek F. van Hulst, Albert van den Berg, David N. Reinhoudt, and Mercedes Crego-Calama
Journal of the American Chemical Society
vol 126 no 23: p7293-p7299 jun 16 2004
Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (CP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.