Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter at the nanoscale.
We do this by exploring ways to shape light and its environment. It's what we call
active and passive control. Our current focus is on the interaction of light with
biomolecules and nanostructures. We are part of Twente
University's Department of Science and Technology and member of the
A Simple Approach to Sensor Discovery and Fabrication on Self-Assembled Monolayers on Glass(full pdf)
Lourdes Basabe-Desmonts, Joris Beld, Rebecca S. Zimmerman, Jordi Hernando, Petra Mela, María F. García Parajó, Niek F. van Hulst, Albert van den Berg, David N. Reinhoudt, and Mercedes Crego-Calama
Journal of the American Chemical Society
vol 126 no 23: p7293-p7299 jun 16 2004
Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (CP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.