Optical Sciences

Biomolecules and nanostructures

The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.

 

Coherent Anti-Stokes Raman Scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

(full pdf)

M. Jurna, M.Windbergs, C. J. Strachan, L. Hartsuiker, C. Otto, P. Kleinebudde, J. L. Herek, and H. L. Offerhaus
Journal of Innovative Optical Health Sciences
vol. 2 issue 1 p37-43 jan 2009

Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate.
This visualization technique can aid future tablet design.
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