Optical Sciences

Biomolecules and nanostructures

The Optical Sciences group studies the interaction of light and matter at the nanoscale. We do this by exploring ways to shape light and its environment. It's what we call active and passive control. Our current focus is on the interaction of light with biomolecules and nanostructures. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.
We participate in the EU-COST actions MP1102: Coherent Raman microscopy (MicroCor) and CM1202: Supramolecular photocatalytic water splitting (PERSPECT-H2O)

 

Coherent Anti-Stokes Raman Scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

(full pdf)

M. Jurna, M.Windbergs, C. J. Strachan, L. Hartsuiker, C. Otto, P. Kleinebudde, J. L. Herek, and H. L. Offerhaus
Journal of Innovative Optical Health Sciences
vol. 2 issue 1 p37-43 jan 2009

Coherent anti-Stokes Raman scattering (CARS) microscopy is used to visualize the release of a model drug (theophylline) from a lipid (tripalmitin) based tablet during dissolution. The effects of transformation and dissolution of the drug are imaged in real time. This study reveals that the manufacturing process causes significant differences in the release process: tablets prepared from powder show formation of theophylline monohydrate on the surface which prevents a controlled drug release, whereas solid lipid extrudates did not show formation of monohydrate.
This visualization technique can aid future tablet design.
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