Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter at the nanoscale.
We do this by exploring ways to shape light and its environment. It's what we call
active and passive control. Our current focus is on the interaction of light with
biomolecules and nanostructures. We are part of Twente
University's Department of Science and Technology and member of the
Phase-shaping strategies for coherent anti-Stokes Raman scattering(full pdf)
A.C.W. van Rhijn, M. Jurna, A. Jafarpour, J.L. Herek and H.L. Offerhaus
Journal of Raman Spectroscopy
Vol. 42, Issue 4, April 2011
The identification of large molecules in complex environments requires probing of multiple vibrational resonances rather than a single resonance. Phase-shaping the excitation pulses allows the coherent mixing of several resonances so that the presence of molecules can be inferred directly from the integrated output pulse energy. This avoids the need for the collection of spectra or multiple measurements. This article describes a particular implementation for coherent anti-Stokes Raman scattering microscopy that uses a broadband pump and probe field in combination with a narrowband Stokes field. We numerically study the possibilities of optimizing selectivity, specificity, and sensitivity by precalculating pulse shapes using an evolutionary algorithm. © 2011 John Wiley & Sons, Ltd.