Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.
Intraoperative Near-Infrared Fluorescence Tumor Imaging with Vascular Endothelial Growth Factor and Human Epidermal Growth Factor Receptor 2 Targeting Antibodies(full pdf)
Anton G.T. Terwisscha van Scheltinga, Gooitzen M. van Dam, Wouter B. Nagengast, Vasilis Ntziachristos, Harry Hollema, Jennifer L. Herek, Carolien P. Schröder, Jos G.W. Kosterink, Marjolijn N. Lub-de Hoog and Elisabeth G.E. de Vries
Journal of Nuclear Medicine
vol. 52 Issue 11 p.1778-1785 nov 1, 2011
Fluorescence imaging is currently attracting much interest as a method for intraoperative tumor detection, but most current tracers lack tumor specificity. Therefore, this technique can be further improved by tumor-specific detection. With tumor-targeted antibodies bound to a radioactive label, tumor-specific SPECT or PET is feasible in the clinical setting. The aim of the present study was to apply antibody-based tumor detection to intraoperative optical imaging, using preclinical in vivo mouse models.