Optical Sciences

Biomolecules and nanostructures

The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.

 

Intraoperative Near-Infrared Fluorescence Tumor Imaging with Vascular Endothelial Growth Factor and Human Epidermal Growth Factor Receptor 2 Targeting Antibodies

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Anton G.T. Terwisscha van Scheltinga, Gooitzen M. van Dam, Wouter B. Nagengast, Vasilis Ntziachristos, Harry Hollema, Jennifer L. Herek, Carolien P. Schröder, Jos G.W. Kosterink, Marjolijn N. Lub-de Hoog and Elisabeth G.E. de Vries
Journal of Nuclear Medicine
vol. 52 Issue 11 p.1778-1785 nov 1, 2011
doi:10.2967/jnumed.111.092833

Fluorescence imaging is currently attracting much interest as a method for intraoperative tumor detection, but most current tracers lack tumor specificity. Therefore, this technique can be further improved by tumor-specific detection. With tumor-targeted antibodies bound to a radioactive label, tumor-specific SPECT or PET is feasible in the clinical setting. The aim of the present study was to apply antibody-based tumor detection to intraoperative optical imaging, using preclinical in vivo mouse models.
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