Optical Sciences

Biomolecules and nanostructures

The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.

 

Distribution of binder in granules produced by means of twin screw granulation

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Margot Fonteyne, Andrew Luke Fussell, Jurgen Vercruysse, Chris Vervaet, Jean Paul Remon, Clare Strachan, Thomas Rades, Thomas De Beer
International Journal of Pharmaceutics
Vol. 462, Issues 1–2, p. 8–10, 28 Feb 2014
doi:10.1016/j.ijpharm.2013.12.008

According to the quality by design principle processes may not remain black-boxes and full process understanding is required. The granule size distribution of granules produced via twin screw granulation is often found to be bimodal. The aim of this study was to gain a better understanding of binder distribution within granules produced via twin screw granulation in order to investigate if an inhomogeneous spread of binder is causing this bimodal size distribution. Theophylline–lactose–polyvinylpyrrolidone K30 (PVP) (30–67.5–2.5%, w/w) was used as a model formulation. The intra-granular distribution of PVP was evaluated by means of hyperspectral coherent anti-Stokes Raman scattering (CARS) microscopy. For the evaluated formulation, no PVP rich zones were detected when applying a lateral spatial resolution of 0.5 μm, indicating that PVP is homogenously distributed within the granules.
© 2013 Elsevier B.V. All rights reserved.
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