Optical Sciences

Biomolecules and nanostructures

The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.


Chromatin structure in bands and interbands of polytene chromosomes imaged by Atomic Force Microscopy

de Grauw CJ, Avogadro A, van den Heuvel DJ, Van der Werf KO, Otto C, Kraan Y, van Hulst NF, Greve J
vol 121 issue 1: p2-p8 JAN 1998

Polytene chromosomes from Drosophila melanogaster, observed from squash preparations, and chromosomes from Chironomus thummi thummi, investigated under physiological conditions, are imaged using an Atomic Force Microscope. Various chromatin fiber structures can be observed with high detail in fixed chromosomes and correspond to structures which are also observed in chromosomes of diploid cells. Unfixed chromosomes can be imaged in buffer and show less fiber-like details because of the inherent soft nature of the chromatin material. (C) 1998 Academic Press.
Printable version