Integrated Optical Sciences
Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter. Our current focus is on detection and sensing/imaging with an emphasis on the development of integrated photonics. We are part of Twente University's Department of Science and Technology and member of the MESA+ institute.
Lithographic patterning of fluorescent molecules
Supramolecular host-guest systems with multivalent interactions between the host and the guest moiety are attractive systems for patterning because of (i) the reversibility of patterning, (ii) the specificity of the host-guest interactions, (iii) the controllable surface affinity, and (iv) the tunability of the host-guest interaction strength. The use of glass substrates covered with a monolayer of cyclodextrin host molecules allows for the patterning and subsequent imaging of fluorescent guest molecules. Fluorescent patterns with a size below the diffraction-limit were written using dip-pen lithography and subsequently imaged using friction-force atomic force microscopy (right image) and fluorescence confocal microscopy with single-molecular sensitivity (left image). Patterns are stable towards rinsing with water and can be erased by rinsing with a cyclodextrin solution.