Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter at the nanoscale.
We do this by exploring ways to shape light and its environment. It's what we call
active and passive control. Our current focus is on the interaction of light with
biomolecules and nanostructures. We are part of Twente
University's Department of Science and Technology and member of the
Lithographic patterning of fluorescent molecules
Supramolecular host-guest systems with multivalent interactions between the host and the guest moiety are attractive systems for patterning because of (i) the reversibility of patterning, (ii) the specificity of the host-guest interactions, (iii) the controllable surface affinity, and (iv) the tunability of the host-guest interaction strength. The use of glass substrates covered with a monolayer of cyclodextrin host molecules allows for the patterning and subsequent imaging of fluorescent guest molecules. Fluorescent patterns with a size below the diffraction-limit were written using dip-pen lithography and subsequently imaged using friction-force atomic force microscopy (right image) and fluorescence confocal microscopy with single-molecular sensitivity (left image). Patterns are stable towards rinsing with water and can be erased by rinsing with a cyclodextrin solution.