Integrated Optical Sciences
Biomolecules and nanostructures
The Optical Sciences group studies the interaction of light and matter at the nanoscale.
We do this by exploring ways to shape light and its environment. It's what we call
active and passive control. Our current focus is on the interaction of light with
biomolecules and nanostructures. We are part of Twente
University's Department of Science and Technology and member of the
Optimizing photodrug efficiency
The photoexcited photosensitizer molecules trigger the formation of singlet oxygen, which leads to cell death. Such functional molecules have been successfully applied in Photodynamic Therapy (PDT) of cancerous tumors. Aiming to improve these applications, we optimized triplet yield in a model photosensitizer.
To extract photophysical insight and to improve the efficiency of photosensitizer molecules used in photomedicine, a femtosecond laser system was applied with adaptive femtosecond pulse shaping based on a Learning-Loop optimization procedure. We used transient absorption spectroscopy to characterize the ultra-fast dynamics of the model photosensitizer. For the coherent-control studies, a pulse-shaper was introduced into the pump beam of the pump-probe setup.